In your article “NSAIDs: Making safer treatment choices”, BPJ 55 (Oct,
2013), the article opened saying that COX-1 was concentrated in the kidney and that COX-1 activity controlled renal perfusion
through catalysing prostaglandins.
Later in the same article you state that medicines that block COX-2 are nephrotoxic because they reduce renal blood
flow by preventing prostaglandin-mediated vasodilation.
My questions are:
- Is renal blood flow COX-1 or COX-2 mediated?
- Are COX-2 inhibitors safer to use in renal impairment?
Dr Bruce Sutherland, General Practitioner
The article “Non-steroidal anti-inflammatory drugs (NSAIDs):
Making safer treatment choices”, BPJ 55 (Oct, 2013),
began with a brief overview of the function of the cyclo-oxygenase (COX) enzymes, with more detailed information in
later sections. Clarification about the role of the COX enzymes in renal function may be necessary to emphasise that
all non-selective non-steroidal anti-inflammatory drugs (NSAIDs) and all COX-2 inhibitors have the ability to cause
adverse renal affects, particularly in patients who are at increased risk.
- Renal blood flow is mainly controlled by the vasodilatory action of prostaglandins produced by the COX-1 enzyme,
which is concentrated in the vascular endothelium.1 However, the flow of blood to the kidney is also influenced
by the activity of the COX-2 enzyme. COX-2 in the kidney largely functions to maintain water and electrolyte balance
and if homeostasis is not maintained then renal perfusion can decrease.1 Studies also indicate that there
is significant overlap between the function of the COX enzymes and that COX-2 also produces prostaglandins that can
cause vasodilation of the renal artery.1, 2
- Clinical trials have demonstrated that non-specific NSAIDs and COX-2 inhibitors have similar risk profiles for people
with reduced glomerular filtration rate (GFR) and in people at risk of pre-renal failure.1 This is because
the vasodilatory effect of COX-1 derived prostaglandins and the ability of COX-2 derived prostaglandins to maintain
water and electrolyte balance is important to maintain renal function. Inhibiting COX-2 reduces the ability of the
kidney to maintain homeostasis which increases the risk to the kidney further by reducing renal perfusion. It would
have perhaps been clearer if it had been specified in the article that both COX-2 inhibitors and non-selective NSAIDs
are potentially nephrotoxic. The statement “medicines that block COX-2 are nephrotoxic” was intended to convey the
potential adverse effects of both types of NSAIDs, because both non-selective NSAIDs and COX-2 inhibitors block COX-2
activity. The statement was not meant to imply that any NSAID-induced renal toxicity was caused exclusively by inhibition
of the COX-2 enzyme.
It is important to remember that the use of either non-selective NSAIDs or COX-2 inhibitors is not recommended in
people at increased risk of renal complications. It should also be kept in mind that the selectivity of NSAIDs is only
relative. For example, meloxicam, a COX-2 inhibitor, mainly inhibits COX-2 at low concentrations but as the concentration
of meloxicam increases adverse effects attributed to inhibition of COX-1 are experienced by patients.3
For further information on the effect of NSAIDs on renal physiology see: NSAIDs, Coxibs,
and Cardio-Renal Physiology:
A Mechanism-Based Evaluation: Coxibs and Renal Physiology. Available from:
- DeMaria A. NSAIDs, coxibs, and cardio-renal physiology: A mechanism based evaluation. Available from:
- Stichtenoth DO, Marhauer V, Tsikas D, et al. Effects of specific COX-2-inhibition on renin release and renal and
systemic prostanoid synthesis in healthy volunteers. Kidney Int. 2005;68(5):2197–207.
- Singh G, Lanes S, Triadafilopoulos G. Risk of serious upper gastrointestinal and cardiovascular thromboembolic
complications with meloxicam. Am J Med. 2004;117(2):100–6.