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Bipolar disorder is characterised by extreme mood swings, but some patients may have milder symptoms, making detection
and diagnosis more challenging. The first mood disturbance often occurs during adolescence, however, first onset bipolar
disorder may also occur in older people. The cause of the disorder is unknown, although there is a strong inheritable
Bipolar I disorder is diagnosed when patients have experienced at least one episode of mania.
Bipolar II disorder is diagnosed when patients have had at least one episode of depression and one episode of hypomania
(a mild episode of mania), but have never experienced an episode of full mania.
A “mixed episode” is where the patient experiences mania and depression during the same period. For example, feeling
hopeless with suicidal thoughts while also feeling highly energised. During a mixed episode, if the patient has reduced
sleep and is drinking alcohol their risk of committing suicide is greatly increased.
Depression is the most common mood disturbance in people with bipolar disorder and therefore the disorder is often initially
diagnosed as depression. Treatment for depression with antidepressant monotherapy can worsen the status of patients with
bipolar disorder, as they usually also require a mood stabiliser.
A formal diagnosis of bipolar disorder is generally carried out by a Psychiatrist. People with bipolar disorder often
- A personal history of mania
- A family history of bipolar disorder
- Problems with alcohol
- Displayed risk taking behaviour, e.g. sexual or financial
- A history of complicated and disrupted circumstances, e.g. multiple relationships
The management of patients with bipolar disorder is usually led by a Psychiatrist. General Practitioners can anticipate
changes in circumstances that make a relapse more likely. At each consultation the clinician should consider:
- Are the patient’s symptoms under control?
- Has there been any change in circumstances that may cause the patient excess stress, e.g. relationship status?
- Has the overall health of the patient changed, e.g. substance use?
Medicines are the mainstay of bipolar disorder treatment, however, self-management is also essential. Patients, with
the help of their families, can improve mood stability by maintaining daily routines including: medicine use, healthy
sleep patterns, exercise and avoidance of alcohol.
Lithium is an effective treatment for acute mania, acute depression and long-term mood stabilisation in people with
bipolar disorder. It has a narrow therapeutic index and patients need to be monitored. Lithium will take up to ten days
to produce an effect in patients who are manic, and up to eight weeks for patients with bipolar depression. Generally,
the patient’s serum lithium is titrated to 0.6 – 0.8 mmol/L; a higher concentration is recommended for acute episodes
of mania, and for patients who have experienced a relapse. Fine tremor and nausea are dose-dependent adverse effects of
lithium treatment that often pass after one to two days. Adverse effects should be anticipated when doses are increased.
Other medicines used in the management of patients with bipolar disorder include: mood stablisers, e.g. valproate and
carbamazepine, atypical antipsychotics, e.g. olanzapine and quetiapine, and antidepressants, e.g. fluoxetine. Patients
will usually require ongoing laboratory monitoring while taking these medicines
Patients with bipolar disorder can be expected to develop more than one psychiatric disorder during their lives, e.g.
Peer group discussion points
- Are you currently involved in the management of any patients with bipolar disorder? If so, what is your role?
- Do you routinely ask patients with depressive symptoms about any history of mania/hypomania?
- Were you aware that maintaining daily routines is thought to provide a clinical benefit to patients with bipolar
disorder, independent to the influence of any pharmacological treatment?
- Local guidelines often vary regarding the titration and monitoring of lithium treatment. What is your experience
of lithium treatment and does it differ to what is outlined in the article?
- Valproate, carbamazepine and lamotrigine are all rated pregnancy risk category D. Do you routinely advise effective
contraception when prescribing any of these medicines to pre-menopausal females?