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New diabetes medicines funded: empagliflozin and dulaglutide

Sodium-glucose co-transporter 2 (SGLT-2) inhibitors and glucagon-like peptide-1 (GLP-1) receptor agonists have been recommended for the treatment of type 2 diabetes for some time, but until now have not been funded in New Zealand. As of 1 February, 2021, empagliflozin, a SGLT-2 inhibitor, has been available fully funded for the treatment of people with type 2 diabetes who are at high risk of cardiovascular disease or have renal complications, including all Māori and Pacific peoples. Dulaglutide, a GLP-1 receptor agonist, has been available fully funded since 1 September, 2021

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Published: 3 May 2021 | updated 7 March 2024


7 March 2024 Updates to text and Table 3 based on changes in the empagliflozin datasheet/indications (can now be used in renal impairment, and in children aged ≥ 10 years)

22 August 2023 Liraglutide information added.

25 August 2021 Dulaglutide funding status updated.

5 July 2021 article revised to appear in Diabetes Special Edition; previous restriction on use of empagliflozin in people with nephrolithiasis/recurrent renal calculi removed


If you would like to know what changes were made when the article was updated please contact us

Key practice points:

  • Lifestyle interventions, i.e. diet and exercise to achieve weight loss, and metformin remain the cornerstone of type 2 diabetes management
  • Empagliflozin, an oral SGLT-2 inhibitor (with or without metformin) and dulaglutide, an injectable GLP-1 receptor agonist, are newly funded options for eligible people with type 2 diabetes to add to lifestyle interventions and metformin
  • Empagliflozin and dulaglutide are funded for people with HbA1c levels > 53 mmol/mol who are at high risk of, or with established, cardiovascular disease, diabetic kidney disease, heart failure or who are of Māori or Pacific ethnicity. Dual treatment with these medicines is not funded.
  • Empagliflozin and dulaglutide reduce the risk of cardiovascular and renal complications in people with type 2 diabetes; empagliflozin in particular reduces hospital admission with heart failure. Both classes of medicine also promote weight loss, especially dulaglutide.
  • Adverse effects of SGLT-2 inhibitors such as empagliflozin can include polyuria and urogenital infections. This medicine class also increases the risk of diabetic ketoacidosis; discuss this risk with patients when initiating treatment and inform them of the key symptoms and signs that should prompt them to seek medical advice.
  • Adverse effects of GLP-1 receptor agonists such as dulaglutide include gastrointestinal disturbance and injection site reactions

Sodium-glucose co-transporter 2 (SGLT-2) inhibitors and glucagon-like peptide-1 (GLP-1) receptor agonists have been recommended internationally in type 2 diabetes management guidelines for some time, but, until now, have been inaccessible to most people in New Zealand due to cost. Empagliflozin (with and without metformin), an oral SGLT-2 inhibitor, has been available fully funded with Special Authority approval since 1 February, 2021 (see: “Initiating funded treatment”).1 As of 1 September, 2021, Dulaglutide, an injectable GLP-1 receptor agonist, has also been available fully funded with Special Authority approval. Both medicines will be the sole subsidised brands until at least 2024.1

SGLT-2 inhibitors lower blood glucose levels by inhibiting glucose reabsorption in the renal tubule. In contrast, GLP-1 receptor agonists lower blood glucose levels by stimulating insulin secretion after meals. When added to metformin, SGLT-2 inhibitors and GLP-1 receptor agonists may reduce HbA1c levels by a further 7 to 15 mmol/mol.2–4

For further information on the decision to fund these medicines, see: https://pharmac.govt.nz/news-and-resources/consultations-and-decisions/decision-to-fund-two-new-medicines-for-type-2-diabetes/

People at high risk of cardiovascular and renal complications will benefit

Several large randomised controlled trials (RCTs) have shown that treatment with a SGLT-2 inhibitor or GLP-1 receptor agonist provides significant cardiovascular benefit to people with type 2 diabetes.5 A recent meta-analysis of 764 RCTs including 421,346 people with type 2 diabetes found that both medicine classes reduced:6

  • All-cause mortality
  • Cardiovascular mortality
  • Non-fatal myocardial infarction
  • Kidney failure

The mechanism by which these medicines reduce adverse cardiovascular outcomes remains uncertain; trials are currently underway to explore the pathways involved, including investigating reductions in oxidative stress and cardiac pre-load.7

Table 1 describes the estimated absolute difference in outcomes with SGLT-2 inhibitors and GLP-1 receptor agonists compared with placebo per 1,000 people with type 2 diabetes with moderate or very high cardiovascular risk.6 *

*Moderate risk defined as people with cardiovascular disease; very high risk defined as people with both cardiovascular disease and chronic kidney disease

Funding criteria is intended to help reduce inequities

For the first time, Māori and Pacific peoples have been specifically identified within Special Authority criteria for funding (see: “Initiating funded treatment” for the full criteria). The prevalence of type 2 diabetes is two to three times higher in these ethnic groups than others.8 Māori and Pacific peoples with type 2 diabetes have worse health outcomes compared to Europeans.9, 10 Improved access to medicines with established cardiovascular and renal benefits is hoped to reduce the inequities in diabetes health outcomes in these vulnerable populations.


Table 1. Estimated absolute differences in outcomes with SGLT-2 inhibitors and GLP-1 receptor agonists compared with placebo per 1,000 people with type 2 diabetes with moderate and very high cardiovascular risk, treated for five years. Adapted from Palmer et al, (2021).6

CVD risk category* All-cause mortality Cardiovascular mortality Non-fatal myocardial infarction Non-fatal stroke Kidney failure Hospital admission for heart failure

SGLT-2 inhibitor

Moderate

25 fewer

(32 fewer – 18 fewer)

12 fewer

(18 fewer – 6 fewer)

13 fewer

(21 fewer – 3 fewer)

1 more

(11 fewer – 13 more)

6 fewer

(9 fewer – 2 fewer)

23 fewer

(28 fewer – 17 fewer)

Very high

48 fewer

(61 fewer – 35 fewer)

24 fewer

(36 fewer – 12 fewer)

21 fewer

(34 fewer – 5 fewer)

2 more

(17 fewer - 21 more)

38 fewer

(58 fewer – 14 fewer)

58 fewer

(73 fewer – 44 fewer)

GLP-1 receptor agonist

Moderate

13 fewer

(18 fewer – 6 fewer)

9 fewer

(15 fewer – 1 fewer)

8 fewer

(15 fewer – 1 fewer)

16 fewer

(24 fewer – 7 fewer)

4 fewer

(7 fewer – 2 fewer)

4 fewer

(11 fewer – 2 more)

Very high

24 fewer

(35 fewer – 12 fewer)

18 fewer

(30 fewer – 6 fewer)

13 fewer

(24 fewer – 2 fewer)

25 fewer

(39 fewer – 11 fewer)

29 fewer

(44 fewer – 10 fewer)

11 fewer

(28 fewer – 5 fewer)

*Moderate risk defined as people with CVD; very high risk defined as people with both CVD and chronic kidney disease

Type 2 diabetes management follows a stepwise progression. Lifestyle interventions and metformin are the cornerstone of type 2 diabetes management (Step 1). If a sufficient reduction in HbA1c levels is not achieved with metformin, treatment is typically escalated by reinforcing the importance of diet and exercise to induce weight loss, and adding a second non-insulin pharmacological treatment (Step 2a). If further intensification is required, a third non-insulin pharmacological treatment can be added (Step 2b) or insulin can be initiated (Step 3).

N.B. Consider starting at Step 2 at diagnosis for patients with HbA1c levels > 64 mmol/mol, i.e. two pharmacological treatments (e.g. metformin and vildagliptin) and lifestyle management.11 Consider initiating insulin at diagnosis if very high HbA1c levels, e.g. > 80 – 90 mmol/mol*, or significant symptoms of hyperglycaemia.11 Insulin may be withdrawn once HbA1c levels are controlled.

*This is a higher level than in previous guidance (75 mmol/mol) due to the availability of more medicines to manage hyperglycaemia12

Treatment options at Step 2 (typically added to metformin) include:

  • Empagliflozin (oral, funded with Special Authority – see: “Initiating funded treatment” and “Prescribing empagliflozin”), taken either as separate metformin and empagliflozin tablets, or a combination empagliflozin + metformin formulation
  • Dulaglutide (injectable, funded with Special Authority – see: “Initiating funded treatment” and “Prescribing dulaglutide”)
  • Vildagliptin (oral, funded), taken either as separate metformin and vildagliptin tablets, or a combination vildagliptin + metformin formulation
  • A sulfonylurea (oral, funded), such as gliclazide or glipizide
  • Pioglitazone (oral, funded)

The decision about which medicine to use should take into account any contraindications, cardiovascular co-morbidities, risk of hypoglycaemia, effects on weight, medicines interactions, adverse effects and eligibility for funding (Table 2 and “Initiating funded treatment”).5

Empagliflozin or dulaglutide are preferred at Step 2 for people with or at high risk of CVD, diabetic kidney disease or heart failure, regardless of their HbA1c levels; currently only people with HbA1c levels > 53 mmol/mol are eligible for funded treatment (see: “Initiating funded treatment”).11 Both medicine classes can be used together with likely additive benefits, however, dual treatment with empagliflozin and dulaglutide is not funded.11 There is little risk of hypoglycaemia with these medicines without concomitant use of sulfonylureas or insulin.

N.B. A SGLT-2 inhibitor or GLP-1 receptor agonist are also preferred in some international guidelines if there is a need to minimise weight gain or promote weight loss, however, they are not funded for these indications in New Zealand.5,13

Vildagliptin is recommended at Step 2 for people with type 2 diabetes who are not eligible for funded SGLT-2 inhibitor or GLP-1 receptor agonist treatment (also see: “Clinical scenarios where empagliflozin or dulaglutide are recommended, but not funded”).11 Vildagliptin is particularly useful in older patients, either combined with metformin or alone if metformin is contraindicated or not tolerated.

A new type 2 diabetes management guideline published by the New Zealand Society for the Study of Diabetes and the Ministry of Health is available here: https://t2dm.nzssd.org.nz/

Table 2. Effects of diabetes medicines (excluding insulin) on HbA1c, cardiovascular co-morbidities, progression of kidney disease, weight and risk of hypoglycaemia and diabetic ketoacidosis. Adapted from the American Diabetes Association (2021) and NZSSD (2021).5, 11

Medicine Efficacy for lowering HbA1c Cardiovascular effects Renal effects: progression of DKD Effects on weight Risk of hypoglycaemia Risk of DKA
CVD HF
Metformin High Potential benefit Neutral Neutral Neutral with potential for modest loss Low Low
Empagliflozin Intermediate Benefit Benefit Benefit Loss Low High
Dulaglutide High Benefit Neutral Benefit Loss Low Low
Vildagliptin Intermediate Neutral Neutral Neutral Neutral Low Low
Sulfonylureas High Neutral Neutral Neutral Gain High Low
Pioglitazone High Potential benefit Increased risk Neutral Gain Low Low

CVD = cardiovascular disease,     HF = heart failure,     DKD = diabetic kidney disease,     DKA = diabetic ketoacidosis

Initiating funded treatment

To initiate funded empagliflozin or dulaglutide treatment, patients must meet either of the following criteria:1

  1. Have type 2 diabetes; and
  2. Have at least one of the following characteristics:
    • Māori or any Pacific ethnicity; or
    • Pre-existing CVD or risk equivalent*; or
    • An absolute five-year CVD risk of ≥ 15% according to a validated cardiovascular risk assessment calculator; or
    • A high lifetime cardiovascular risk due to being diagnosed with type 2 diabetes during childhood or as a young adult; or
    • Diabetic kidney disease; and
  3. Have an HbA1c level > 53 mmol/mol despite the regular use of at least one blood-glucose lowering agent (e.g. metformin, vildagliptin or insulin) for at least three months**

Or

Have previously received an initial approval for a SGLT-2 inhibitor if the current application is for a GLP-1 agonist, or vice versa

*Defined as: prior cardiovascular disease event (i.e. angina, myocardial infarction, percutaneous coronary intervention, coronary artery bypass grafting, transient ischaemic attack, ischaemic stroke, peripheral vascular disease), congestive heart failure or familial hypercholesterolaemia

Defined as: persistent albuminuria (albumin:creatinine ratio greater than or equal to 3 mg/mmol, in at least two out of three samples over a 3 – 6-month period) and/or eGFR less than 60 mL/min/1.73m2 in the presence of diabetes, without alternative cause

** If HbA1c is very high at diagnosis, e.g. > 64 mmol/mol, they would not be eligible for funded treatment with empagliflozin or dulaglutide until they have been treated with at least one glucose-lowering agent for three months; patients with high HbA1c at diagnosis could be initiated on metformin + vildagliptin or, if HbA1c are very high at diagnosis, metformin and insulin (which could then be withdrawn once HbA1c has stabilised)

Applications can be made by any relevant practitioner and are valid without further renewal (unless notified) for eligible patients. Dual SGLT-2 inhibitor/GLP-1 receptor agonist treatment is not currently funded.

A calculator to assess cardiovascular disease risk in people with type 2 diabetes is available here: https://www.nzssd.org.nz/cvd/

Choosing between empagliflozin and dulaglutide

The decision to initiate a SGLT-2 inhibitor versus a GLP-1 receptor agonist is based primarily on the predominant co-morbidity, i.e. CVD, heart failure or diabetic kidney disease, and patient preference, particularly regarding the route of administration (Figure 1).11 If heart failure or diabetic kidney disease predominates, a SGLT-2 inhibitor (i.e. empagliflozin) is preferred. Otherwise either a SGLT-2 inhibitor or a GLP-1 receptor agonist (i.e. dulaglutide) is recommended; GLP-1 receptor agonist treatment will likely lead to greater improvements in glycaemic control and greater weight loss than SGLT-2 inhibitor treatment (although SGLT-2 inhibitors are still associated with weight loss).11

An interactive decision support tool is available here: https://magicevidence.org/match-it/200820dist/#!/

Dulaglutide is administered as a once weekly injection

Patients may be reluctant to take dulaglutide as it is an injectable treatment rather than an oral medicine. However, unlike insulin, which requires one or more daily injections, dulaglutide is administered once weekly. Furthermore, self-monitoring blood glucose is not necessary for patients taking dulaglutide, unless their regimen also includes a sulfonylurea or insulin. Providing patients who are hesitant about initiating an injectable treatment with this information may help them to feel more confident with this treatment option. A treatment trial of dulaglutide may be very useful before initiating insulin.


Figure 1. An overview of management of patients with type 2 diabetes. Adapted from the New Zealand Society for the Study of Diabetes type 2 diabetes guideline (2021).11

When initiating empagliflozin, reinforce lifestyle advice, i.e. dietary and exercise interventions, and offer support as required. Metformin should be continued unless it is contraindicated or not tolerated; combination empagliflozin + metformin formulations are available (Table 3).11 Other glucose-lowering treatments (e.g. vildagliptin, a sulfonylurea, dulaglutide,* or insulin) should be continued if needed for glycaemic control or cardiovascular or renal protection.11 If the patient is taking insulin or a sulfonylurea, the dose may need to be reduced; a reduction of 15 – 20% of the daily total insulin or 50% of the sulfonylurea dose is recommended as a starting point.11 People with a HbA1c > 75 mmol/mol do not usually require a reduction in insulin or sulfonylurea, unless they have a history of hypoglycaemia.11 Patients taking SGLT-2 inhibitors must discontinue treatment during an acute illness or two days before an elective medical procedure.11

*Dual empagliflozin and dulaglutide treatment is not currently funded under the Special Authority criteria

For further information on sick-day management, see: https://t2dm.nzssd.org.nz/Section-95-Sick-day-management-in-patients-with-diabetes


Table 3. Key empagliflozin prescribing information.11, 14, 15

Formulation Dose information Notes
Empagliflozin 10 mg and 25 mg, tablet
  • Initiate at 10 mg daily
  • Increase to maximum of 25 mg daily after several weeks if no adverse effects AND as required for glycaemic control
  • Maximum dose 10 mg, once daily, in patients with eGFR < 30 mL/min/1.73m2 (efficacy of empagliflozin likely reduced as it is dependent on renal function, so additional glucose lowering treatment may be required)
  • Not recommended in patients on dialysis
  • No dose adjustment required for people with mild renal impairment
Empagliflozin with metformin hydrochloride 5 mg empagliflozin with 500 mg or 1000 mg metformin, tablet
  • Initiate at 5 mg empagliflozin twice daily (10 mg total daily dose); choose the dose of metformin similar to the dose already being taken
  • Contraindicated for people with eGFR < 30 mL/min/1.73 m2 due to metformin component
12.5 mg empagliflozin with 500 mg or 1000 mg metformin, tablet
  • Maximum recommended daily dose is 25 mg empagliflozin and 2000 mg metformin
  • Reduce metformin dose for people with renal impairment; no empagliflozin dose adjustment is required for people with mild renal impairment

Contraindications and cautions to empagliflozin treatment

If the patient’s eGFR is < 30 mL/minute/1.73 m2, the maximum recommended dose of empagliflozin is 10 mg, once daily. However, efficacy is dependent on renal function, and empagliflozin may be ineffective at reducing glucose levels in patients with this degree of renal impairment; additional glucose lowering treatment should be considered, as needed.14 Empagliflozin should not be taken by patients on dialysis.14

Empagliflozin is not recommended for use in people with type 2 diabetes who:11

  • Are pregnant or breastfeeding
  • Have a history of severe genitourinary infections
  • Are on a ketogenic diet (due to the increased risk of diabetic ketoacidosis – see below)

N.B. Previously, empagliflozin was only approved for use in people with type 2 diabetes aged ≥ 18 years. Since November, 2023, empagliflozin is now indicated in people aged ≥ 10 years as a monotherapy if metformin is not tolerated (and diet and exercise alone do not provide adequate glycaemic control), or in combination with other glucose-lowering medicines (under specialist supervision) if glycaemic control remains poor.

Cautions. Use of empagliflozin in people with nephrolithiasis/recurrent renal calculi was previously not recommended in the NZSSD guidance. However, updated advice is that empagliflozin may be used with caution in patients with a history of renal calculi if good hydration is ensured; extra caution is needed in those with recurrent calculi. Caution is also required when using empagliflozin in patients aged ≥ 75 years as they may be at risk of volume depletion.14 Use was previously not recommended in patients aged ≥ 85 years, but this advice has been removed from the datasheet (Nov, 2023).

For further information, refer to the New Zealand Formulary: https://www.nzf.org.nz/nzf_70809

Discuss potential adverse effects before initiating treatment

Adverse effects of SGLT-2 inhibitors such as empagliflozin include:11

  • Polyuria – consider reducing diuretics before initiating treatment
  • Genitourinary infections, e.g. urinary tract infection, vaginal thrush, balantitis – this is thought to be due to the increased urinary excretion of glucose. Ensure patients are given information on hygiene measures and the rare risk of necrotising fasciitis of the perineum (Fournier’s gangrene).
  • Hypotension – consider reducing antihypertensive medicines before initiating treatment or before a dose increase
  • Diabetic ketoacidosis (DKA) – increased risk (see below)

SGLT-2 inhibitor use is associated with an increased risk of severe DKA

People taking SGLT-2 inhibitors are at increased risk of DKA, particularly in the first few months of treatment or peri-operatively.11 This can occur with normal blood glucose levels (euglycaemia).11 While this is a rare adverse effect (ranging from one in 1,000 to one in 3,000 people), this should be discussed with patients before initiating treatment, with advice provided on the symptoms and signs of DKA and when to seek medical attention to get their blood ketones checked (i.e. if they experience nausea, vomiting or abdominal pain).11 In general, it is advisable to temporarily stop empagliflozin if patients are unwell and febrile, especially if they are not eating or vomiting.

N.B. Patients with type 2 diabetes taking a SGLT-2 inhibitor do not currently qualify for a funded CareSens Dual glucometer (measures both blood glucose and blood ketone levels).

For further information on SGLT-2 inhibitors and DKA, see: https://diabetessociety.com.au/documents/ADS_DKA_SGLT2i_Alert_update_2020.pdf

When initiating dulaglutide (Table 4), reinforce lifestyle advice and offer support as required, and provide information on how to administer treatment (see below). Metformin should be continued unless it is contraindicated or not tolerated.11 Dipeptidyl peptidase-4 (DPP-4) inhibitors (i.e. vildagliptin) must be stopped before initiating a GLP-1 receptor agonist as they have similar mechanisms of action.11 Other glucose-lowering treatments can be continued if needed for glycaemic control or cardiovascular or renal protection, with the dose of insulin or a sulfonylurea reduced to prevent hypoglycaemia, if required (see: “Prescribing empagliflozin” for guidance on dose reduction).11 Advise patients to stop treatment if they have an acute gastrointestinal illness (and resume treatment once they have recovered).11


Table 4. Key dulaglutide prescribing information.11, 16

Funded GLP-1 receptor agonist* Formulation Dose information
Dulaglutide 1.5 mg per 0.5 ml prefilled pen, injectable
  • Administered subcutaneously, once weekly; each pen contains one dose of dulaglutide and should only be used once

*Other non-funded GLP-1 receptor agonists approved in New Zealand include liraglutide, exenatide and exenatide extended release (soon to be withdrawn from the local market)

Dulaglutide administration guide:16

  • Dulaglutide is administered once weekly, at any time of day, with or without food
  • Patients can inject dulaglutide in the abdomen, thigh or upper arm
  • Injection sites should be rotated with each dose
  • If a dose is missed, it should be administered as soon as possible if there are ≥ 3 days until the next scheduled dose; if < 3 days until the next dose, the missed dose should not be taken, and the next dose taken at the normal time
  • If the regimen includes insulin, these should be administered as separate injections, i.e. not mixed. If injected in the same body region, ensure the injections are not next to each other.
  • The single-use pen should be disposed of in a specified sharps container or a closable puncture-resistant container, i.e. not in the household rubbish*

*Community pharmacies and some Diabetes NZ branches offer sharps disposal services; patients can return their sharps in a specified sharps container (available to purchase) or other suitable container.

Patient instructions for use of dulaglutide (with images) are available from: https://uspl.lilly.com/trulicity/trulicity.html#ug

Contraindications and cautions to dulaglutide treatment

Dulaglutide is contraindicated in people with personal or family history of medullary thyroid carcinoma or a personal history of multiple endocrine neoplasia syndrome type 2.11, 16 Rodent studies have shown an increased incidence of thyroid C-cell adenomas and carcinomas with GLP-1 receptor agonist treatment.17 While a causal relationship has not been established and there is no evidence of increased prevalence of any form of thyroid cancer in humans with long-term use, dulaglutide is not recommended for use in people at increased risk of thyroid cancer, e.g. due to family history, radiation exposure.11 Advise patients prescribed dulaglutide to seek medical advice if they develop any symptoms that could indicate thyroid cancer, e.g. a mass in the neck, dysphagia, dyspnoea, persistent hoarseness.16

Dulaglutide is not recommended for people:11

  • Aged < 18 years
  • Who are pregnant or breastfeeding
  • With severe gastrointestinal disease, including gastroparesis
  • With previous pancreatitis

Mild adverse effects with dulaglutide are usually transient

Common adverse effects of GLP-1 receptor agonists include gastrointestinal disturbance (nausea [most common], vomiting, anorexia and diarrhoea) and injection site reactions (e.g. nodules, pruritus, bruising, erythema).11, 18 These are usually transient and improve with continued treatment.11 Rare adverse effects include pancreatitis, myalgias and muscle weakness, Stevens-Johnson’s syndrome and thrombocytopaenia.11

Liraglutide; an alternative funded GLP-1 receptor agonist

There are ongoing supply issues for dulaglutide (Trulicity) due to a significant increase in global demand for GLP-1 agonists.1 In response, Pharmac has temporarily funded liraglutide (Victoza*), another GLP-1 receptor agonist, from 1 March, 2023.1 To be initiated on funded liraglutide, patients must meet the same Special Authority criteria as for dulaglutide or empagliflozin (see: “Initiating funded treatment”).1

Following resolution of the supply issues (date uncertain), only patients who have already been initiated on liraglutide will be eligible to continue funded treatment.1 New patients who meet Special Authority criteria will be started on dulaglutide.

*Another brand of liraglutide (Saxenda) is approved for use in New Zealand as an adjunctive treatment for weight loss but this not currently funded for any indication.

Choosing liraglutide

Liraglutide is also an injectable GLP-1 receptor agonist, however, it is administered daily. The glucose-lowering effect of daily doses of 1.8 mg liraglutide are generally equivalent to weekly doses of 1.5 mg dulaglutide.2 All GLP-1 receptor agonists can be associated with adverse gastrointestinal effects, however, diarrhoea is reported more often with liraglutide compared to dulaglutide,3,4 likely due to the more frequent dosing regimen. Liraglutide may be preferred in patients who are unable to tolerate dulaglutide or if dulaglutide is unavailable.3

Prescribing liraglutide

Considerations when initiating liraglutide are the same as when initiating dulaglutide (see: “Prescribing dulaglutide”).

Table 5. Liraglutide prescribing information.3,5,6

Funded GLP-1 receptor agonist* Formulation Dose information Notes
Liraglutide (Victoza) 6 mg/mL prefilled pen, injection
  • Initially 0.6 mg subcutaneously, once daily for one week, then increase to 1.2 mg subcutaneously, once daily
  • Increase to 1.8 mg subcutaneously, once daily if HbA1c target not reached or blood glucose levels remain elevated (also see: “Higher doses of liraglutide for weight loss”)
  • New Zealand guidelines recommend patients already prescribed dulaglutide who need to be switched to liraglutide (due to supply issues) should be initiated on the lowest dose

N.B. Rate of titration can be modified depending on tolerance

  • Renal function should be assessed before initiating liraglutide
  • Dose adjustment is not required for patients with mild to moderate renal impairment although there is an increased risk of adverse effects
  • Liraglutide should not be prescribed to patients with a creatinine clearance < 30 mL/min
  • Dose adjustment is not required in patients with hepatic impairment

*Another brand of liraglutide (Saxenda) is approved for use in New Zealand as an adjunctive treatment for weight loss but this not currently funded for any indication.

Liraglutide administration guide3,5

  • Liraglutide is administered once daily, with or without food, at a consistent time each day
  • Patients can inject liraglutide in the abdomen, thigh or upper arm (if assisted). Injections can be given in the same area of the body, but in a different site for each dose.
  • If a dose is missed, it should be administered as soon as possible within 12 hours of the planned dose; if < 12 hours until the next dose, the missed dose should not be taken, and the next dose taken at the normal time
  • Patients should stop treatment if they have an acute gastrointestinal illness (and resume treatment once they have recovered)
  • Liraglutide should be prescribed with needles. These will be funded if included on the same prescription form or if appropriately endorsed. Needles should be no longer than 8 mm and no finer than 32G, (ideally BD 4 or 5 mm needles).
  • Needles should be removed for storage and disposed of in a specified sharps container or a closable puncture-resistant container, i.e. not in the household rubbish

Contraindications and cautions to liraglutide treatment

Liraglutide is not recommended in patients with inflammatory bowel disease or diabetic gastroparesis due to the increased risk of gastrointestinal adverse effects.5 Liraglutide should be used with caution in people with severe congestive heart failure, or a history of thyroid disease or pancreatitis.5,6 Liraglutide should also be avoided in people who are pregnant.3

N.B. Liraglutide is not currently approved for use in people aged under 18 years, however, there is now evidence of the safety and efficacy of liraglutide or dulaglutide in people aged 10 – 17 years with type 2 diabetes so it may be considered in some patients "off-label" in consultation with a diabetes specialist.3,7,8

Liraglutide can increase the risk of hypoglycaemia in patients already taking a sulfonylurea or insulin.5 Blood glucose monitoring is required in these patients and reductions in sulfonylurea or insulin dosing may be necessary (see: “Prescribing empagliflozin” for guidance on dose adjustments).5

Adverse effects of liraglutide treatment

Adverse effects associated with the use of liraglutide are similar to those with the use of dulaglutide,2,4 however, an increased risk of gastrointestinal effects, specifically diarrhoea,4 and injection site reactions (with daily dosing) means liraglutide may be less well tolerated. For information about adverse effects of GLP-1 receptor agonists in general, see: “Mild adverse effects with dulaglutide are usually transient

Higher doses of liraglutide for weight loss

While the maximum approved dose of liraglutide (Victoza) for type 2 diabetes is 1.8 mg subcutaneously, once daily,5 evidence has shown some patients may experience added weight loss benefits from higher doses, e.g. 3 mg, once daily.9 However, current funding restrictions only allow three 3 mL liraglutide pens (6 mg/mL), per month.10 This equates to a 30-day supply if approved dosing is prescribed, i.e. 1.8 mg, once daily. If there is a clinical reason to prescribe a higher dose, i.e. weight loss, clinicians should discuss self-funding the Saxenda brand of liraglutide with the patient.

N.B. Dulaglutide is not approved for weight loss in New Zealand.


References

  1. Pharmac. Liraglutide (Victoza): Funded from 1 March 2023. 2023. Available from: https://pharmac.govt.nz/medicine-funding-and-supply/medicine-notices/liraglutide/ (Accessed Jun, 2023).
  2. Dungan KM, Povedano ST, Forst T, et al. Once-weekly dulaglutide versus once-daily liraglutide in metformin-treated patients with type 2 diabetes (AWARD-6): a randomised, open-label, phase 3, non-inferiority trial. The Lancet 2014;384:1349–57. doi:10.1016/S0140-6736(14)60976-4
  3. New Zealand Society for the Study of Diabetes. Type 2 diabetes management guidance; updated 2023 recommendations from NZSSD. 2023. Available from: https://t2dm.nzssd.org.nz/Home.html (Accessed Jun, 2023).
  4. Bettge K, Kahle M, Abd El Aziz MS, et al. Occurrence of nausea, vomiting and diarrhoea reported as adverse events in clinical trials studying glucagon-like peptide-1 receptor agonists: a systematic analysis of published clinical trials. Diabetes Obes Metab 2017;19:336–47. doi:10.1111/dom.12824
  5. Novo Nordisk Pharmaceuticals Ltd. VICTOZA New Zealand Datasheet. 2022. Available from: https://www.medsafe.govt.nz/profs/datasheet/v/Victozainj.pdf (Accessed Jun, 2023).
  6. New Zealand Formulary (NZF). NZF v133. Available from: www.nzf.org.nz (Accessed Aug, 2023).
  7. Tamborlane WV, Barrientos-Pérez M, Fainberg U, et al. Liraglutide in children and adolescents with type 2 diabetes. N Engl J Med 2019;381:637–46. doi:10.1056/NEJMoa1903822
  8. Arslanian SA, Hannon T, Zeitler P, et al. Once-weekly dulaglutide for the treatment of youths with type 2 diabetes. N Engl J Med 2022;387:433–43. doi:10.1056/NEJMoa2204601
  9. Haddad F, Dokmak G, Bader M, et al. A comprehensive review on weight loss associated with anti-diabetic medications. Life 2023;13:1012. doi:10.3390/life13041012
  10. Pharmac. Pharmaceutical Schedule. 2023. Available from: https://schedule.pharmac.govt.nz/2023/07/01/Schedule.pdf (Accessed Jun, 2023)

Regular review of treatment is necessary for all patients with type 2 diabetes to optimise individual goals and ensure medicine regimens remain appropriate. Nutrition, physical activity and body weight monitoring should be discussed with patients at all stages of management. HbA1c levels should be checked every three months if they are above target and the treatment regimen has changed.11 Once target HbA1c levels have been achieved, repeat measurement every six months and complete a diabetes review annually.11 Renal function should be assessed at least annually in patients taking empagliflozin (with or without metformin) and prior to initiating any medicines that may reduce renal function.14 No additional monitoring is required for patients taking dulaglutide.

Acknowledgement

Thank you to Dr Rick Cutfield, Clinical Director of Endocrinology & Diabetes, Waitematā DHB for expert review of this article.

N.B. Expert reviewers do not write the articles and are not responsible for the final content. bpacnz retains editorial oversight of all content.


Narayanan Rajan 1 Feb 2023 19:28

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