Key practice points:
- The overriding principle of weight loss is that energy intake needs to be less than energy expenditure; there is no
consistent evidence that any one calorie-restricted diet is better than another at achieving weight loss.
- The two most important factors when considering the benefit of a dietary regimen are:
- Is the diet healthy, i.e. balanced, nutritious and energy appropriate?
- Can the diet be maintained long-term?
- At least 2.5 hours of moderate intensity physical activity per week should be included in all weight loss interventions
- Contrary to popular belief, rapid weight loss is not associated with an increased risk of weight regain compared to
gradual weight loss
- Pharmacological interventions for weight loss generally have limited long-term effectiveness, however, short-term
use may be considered for people who are obese as an adjunct to lifestyle interventions, after the potential harms and
benefits of treatment have been reviewed
- Bariatric surgery is an effective weight loss intervention that is publicly funded for selected people according to
a national scoring system
The proportion of the New Zealand population who are obese is growing. In 2017/18, almost one-third of New Zealand adults
(1.26 million) were obese.1 There are, however, marked differences in the rates of obesity for some groups;
Māori (48%) and Pacific peoples (65%) are more likely to be obese than European/Others (31%) and Asians (15%).1 People
living in the most deprived communities are 1.6 times more likely to be obese than those living in the least deprived.1
Halting the obesity epidemic requires societal change at a population level. While primary health care professionals
may not be able to address all the health determinants of obesity, on an individual level they can encourage patients
to have healthy lifestyles that prevent excessive weight gain and offer interventions and support to people who would
benefit from a reduction in bodyweight.
The benefits of weight loss
An unhealthy diet and elevated body mass index (BMI) are the two leading individual risk factors for illness, disability
and premature death in New Zealand.2 Excessive body weight is associated with type 2 diabetes, hypertension,
cardiovascular disease, atrial fibrillation, reduced mental health, gout, osteoarthritis, non-alcoholic fatty liver disease,
some cancers, reduced fertility and obstructive sleep apnoea.3
The clinical benefits of weight loss begin once an overweight person loses as little as 5% of their body weight and
benefits increase as the ideal weight range is approached.
Simply advising people to lose weight makes them more likely to try
All health professionals should raise the issue of weight loss if a person is likely to benefit from a reduction in
body weight. A meta-analysis of 12 studies found that people who were advised to lose weight by a health professional
in primary care were almost four times more likely to attempt to do so than those who did not receive this advice.4
Weight loss for the prevention and treatment of diabetes
Obesity is contributing to the increasing rate of type 2 diabetes in New Zealand, most notably in people aged under
40 years. The outcomes for these people are worse than for adults diagnosed later in life as end-organ damage, e.g. diabetic
kidney disease, retinopathy and neuropathy, develop over time and the lifetime risk of cardiovascular disease and early
mortality is higher at a younger age.5
Lifestyle change can prevent type 2 diabetes in people who are overweight or obese
A randomised trial of 3,234 people without diabetes but with elevated fasting glucose and a mean BMI of 34 kg/m2 found
that a lifestyle intervention aiming for ≥ 7% reduction in bodyweight, including a nutritionally balanced, low calorie,
low fat dietary regimen and at least 150 minutes of exercise per week, was effective at preventing the onset of diabetes.6 The
number needed to treat for three years to prevent one case of type 2 diabetes with lifestyle interventions was approximately
Remission of type 2 diabetes with weight loss
A substantial number of people with type 2 diabetes who are overweight can achieve a non-diabetic state if they are
able to lose enough body weight. This was demonstrated by the DiRECT trial which involved 306 primary care patients in
the United Kingdom with a BMI of 27–45 kg/m2 and a mean HbA1c of 60 mmol/mol who had been diagnosed
with type 2 diabetes in the past six years and were not using insulin.7 The intervention involved half the
group having their meals replaced with a nutritionally balanced liquid diet (825–853 kcal per day) for three to five months.7 At
the start of the intervention all glucose-lowering and antihypertensive medicines were withdrawn and participants were
provided with diet and lifestyle advice and monthly follow-ups.7 At 12 months the mean weight of the intervention
group had fallen by 10% and 46% of individuals had achieved diabetes remission, i.e. a sustained HbA1c less
than 48 mmol/mol.7 At 24 months the mean weight loss of the intervention group was 7.6% and 36% had diabetes
remission.8 Remission of diabetes was strongly correlated with the degree of weight loss; at 12 months 86%
of people who lost 15 kg or more achieved remission, compared to 7% of those who lost less than 5 kg.7
The DiRECT trial successfully demonstrated that type 2 diabetes can be reversed with weight loss. However, the intervention
in this study was intensive and may be difficult to achieve in the “real world” without the accompanying health care resources
and support. The balance of evidence suggests that the magnitude of weight loss is the key factor in achieving diabetes
remission and it does not matter how this is achieved, as long as it is sustainable.9
Weight loss improves cardiovascular outcomes in people with diabetes
If people with diabetes do not achieve remission after losing weight, it is likely that they will still benefit from
the improved cardiovascular outcomes associated with weight loss. For example, the Look AHEAD trial in overweight or obese
people with type 2 diabetes found that each 7% reduction in bodyweight was associated with a 15% reduction in the risk
of cardiovascular death, myocardial infarction, stroke or hospitalisation due to angina.10
The overriding principle of weight loss is that people need to consume less energy than they are expending. It is also
critically important that any lifestyle changes that result in weight loss are sustainable otherwise the reduction in
body weight will not be maintained. Therefore, dietary interventions need to be affordable and recognise the cultural
and social significance of food. For example, manaakitanga in Māori culture centres on generous hospitality often involving
food, and this concept is shared by many other Pacific cultures. People need to be able to continue to enjoy eating and
participate in social events that involve food.
Assessing people who are overweight
Before a person begins a weight loss regimen, optimise the management of any co-morbidities. Also consider potential
causes of weight gain including adverse effects of medicines, e.g. corticosteroids, sulphonyureas, insulin, antipsychotics,
and undiagnosed conditions, e.g. polycystic ovary syndrome, hypothyroidism.11
Measure HbA1c levels and undertake a cardiovascular risk assessment from age 35 years in males who are obese
and 45 years in females who are obese; begin CVD risk assessment five years earlier in Māori, Pacific and South-Asian
Monitoring body weight
Guidelines recommend recording BMI and waist circumference* initially to guide discussions about the risks
associated with excess body weight, and then monitoring weight regularly.3 In practice, however, some patients
find being weighed embarrassing or a cause of anxiety and may avoid consultations because of this. Consider the patient’s
preference and decide together whether measuring weight and tracking changes will help or hinder progress, e.g. if a person
is visibly obese measuring weight will not change management advice. Most patients will agree to monitor their own weight
at home; ensure they understand that an overall downward trend is the goal and transient increases or plateaus in weight
are not uncommon and should not be cause for losing motivation.
* A waist circumference > 80 cm in females and > 94 cm in males is associated with an
increased risk of type 2 diabetes, hypertension and cardiovascular disease; a waist circumference > 88 cm in females
and > 102 cm in males substantially increases this risk.11
Rapid weight loss is not associated with an increased risk of weight regain
It was previously recommended that the optimal rate of weight loss was 1 – 4 kg per month due to concerns that more
rapid rate weight loss would encourage unsustainable changes in lifestyle and inevitable weight regain. Evidence now shows
that rapid weight loss, e.g. a 15% reduction in body weight in three months, is associated with the same risk of weight
regain after two years, compared to a 15% reduction in body weight over nine months.13 Rapid weight loss, however,
may be associated with a slightly increased risk of cholecystitis.13
Review the use of medicines as weight loss occurs
People who are obese are often taking medicines to reduce their cardiovascular risk. As weight loss occurs it is appropriate
to review the use of these medicines. For example, weight loss is often associated with a decrease in blood pressure,
which may mean that a reduction in the dose or number of antihypertensives is needed. Glucose-lowering medicines may also
require dose adjustments or withdrawal if glycaemic control improves.
Talk to people about their lifestyle
It is important to gain insight into a person’s lifestyle before providing them with specific advice. This discussion
- A description of the types and amount of food and drink consumed in a typical week
- How meals are prepared and by whom
- The amount and intensity of physical activity per week
- Previous attempts at weight loss
The discussion should be non-judgemental so the patient feels they can provide honest answers without feeling embarrassed
The aim of weight loss advice should be achievable goals.3 Recommendations may start with simple changes,
e.g. switching sugar-sweetened drinks for water, and gradually expand to overall lifestyle change (see: “Discussion
points for a healthy lifestyle”). Motivational interviewing may encourage people to make changes by expressing empathy
about the barriers to change and collectively devising strategies to overcome them. A good way to ensure the patient has
understood is to ask them to explain the information back to you.
Further information on motivational interviewing is available from:
Discussion points for a healthy lifestyle
Encourage people to prepare meals from unprocessed ingredients and to use recipes if they lack knowledge or confidence.
Include caregivers or a partner in the discussion if they are responsible for purchasing and preparing the meals.
Vegetables and fruit should be eaten most frequently, along with wholegrain and high-fibre foods and lean, skinless
sources of protein with some reduced fat dairy products, oils and nuts.
Read food labels. Discuss how to identify the amount of total energy, sugar and saturated fat in food products.
The Health Star Rating system helps consumers compare the overall nutritional value of similar packaged foods, e.g. the
fat, sugar, fibre and protein content. The more stars a product has the higher its overall nutritional value. This system,
however, is not designed to compare the nutritional value of different types of food, e.g. breakfast cereals with yoghurts.
The importance of eating complex carbohydrates. Encourage people to choose high-fibre options such as wholegrain
foods, legumes, brown rice, beans, and fruit and vegetables with the skin on. Consuming 25–29 g of dietary fibre per day
is associated with a 15–30% decrease in cardiovascular and all-cause mortality, coronary heart disease, stroke incidence
and mortality, type 2 diabetes and colorectal cancer, compared to a low-fibre diet.29 There is a strong dose-response
relationship between intake of dietary fibre and whole grains and a number of these conditions.29
Starchy vegetables that are traditional in many cultures are energy dense, e.g. kumara, potato, rice
and taro, and should be eaten in moderation.
A vegetable garden is a cost-effective way of producing fresh vegetables that also increases activity
levels. Vegetable gardens in community hubs are becoming increasingly popular.
Plain water should be the first-choice drink in preference to soft drinks and fruit juice that have
a high sugar content. Free sugar* should be less than 10% of a person’s total dietary energy intake and ideally
less than 5%.11 The addition of ice, sliced fruit or herbs, e.g. mint, can make plain water more enjoyable.
* Includes added sugar and sugars naturally present in fruit juice, syrup and honey
Reduce alcohol intake. In addition to other adverse health effects, ethanol contains almost twice as
much energy per gram as protein or carbohydrates. In general, the greater the percentage of alcohol in a drink the more
energy it contains, and mixers are likely to contain additional calories.
Avoid eating food late in the day as this has been associated with slower weight loss in people who
are trying to lose weight and may be associated with higher levels of serum triglycerides and LDL cholesterol.30
Insufficient sleep is associated with increased energy intake and weight gain.3 In addition
to supporting weight loss, improving sleep quality may result in better mental health, increased alertness and improved
quality of life.
Further information on improving sleep is available from:
The Heart Foundation has a selection of approximately 300 healthy recipes available from:
Handouts for patients including healthy eating, activity advice and serving size guides are available from:
The food pyramid has been replaced by the healthy heart visual food guide that indicates the relative quantities of
food groups that should be eaten. Versions in Te Reo Māori and a number of Pacific Island and Asian languages are available
Tools such as the Diabetes New Zealand “Take Control” app can provide recipes:
A list of fibre-rich foods is available from:
FoodSwitch is a smartphone app that can scan the barcodes of packaged foods. It provides nutritional information about
foods and can suggest similar foods that are healthier:
Recommending a healthy dietary regimen
Key features of calorie-restricted diets that are effective for weight loss are summarised in Table 1. In general, the
weight loss efficacy of energy-matched dietary regimens with different macronutrient compositions, e.g. low carbohydrate
or low-fat, is similar. However, regimens that minimise or “forbid” the intake of particular food groups may result in
nutritional deficiencies, e.g. insufficient fibre, iron or calcium, or excessive intake of saturated fat.
The two most important factors, therefore, in determining the benefit of a dietary regimen are:11
- Is the diet healthy, i.e. balanced, nutritious and energy appropriate?
- Can the diet be maintained long-term, e.g. is it affordable, sustainable within a person’s lifestyle and culturally
and socially acceptable?
Referring to a dietitian
People with sub-optimal nutrition may benefit from a discussion with a dietitian. Subsidised consultations for people
who are obese are generally for those with diabetes and uncontrolled hyperglycaemia, although referral criteria differ
between DHBs. Dietitians are also available privately.
The contact details for local dietitians are available from: https://dietitians.org.nz/
Table 1: Dietary regimens with evidence of effectiveness for weight loss or reduced CVD risk3
Vegetables and fruit are central, monounsaturated fats are prominent, sourced mainly from olive oil. Includes
cereals, nuts and legumes, a moderate amount of poultry, fish and dairy products and little or no red meat.
A substantial amount of supporting short and long-term evidence, including a lower risk of cardiovascular events,
reduced triglycerides, a reduced risk of diabetes and lower HbA1c.14
Serving sizes are not specified and it can be difficult to estimate calorie intake. Iron intake may be insufficient
and supplementation may be required.
Dietary approach to stop hypertension (DASH)
Includes vegetables, fruits, fish, nuts and low-fat dairy products that are naturally low in sodium. Red meat
may be eaten in moderation.
Associated with lower blood pressure and a reduced risk of cardiovascular disease, diabetes and cancer.14
Serving sizes are not specified and it can be difficult to estimate calorie intake.
Very low carbohydrate*
Contains < 20% of total energy from carbohydrate (20–60 g per day). Red meat, poultry, fish, shellfish and
eggs are the primary source of nutrition. The saturated fat content may be particularly high in versions marketed as
Associated with reductions in blood pressure, increased HDL-C and lower triglycerides, and reductions in HbA1c.14 Ketogenesis
may cause a reduction in appetite.15
Fibre and micronutrient consumption may be inadequate, consumption of saturated fat may be excessive. High levels
of animal protein are associated with increased insulin resistance.16
Typically hard to sustain and therefore often used for short periods.
Very low energy*
Typically used for rapid weight loss over 8–12 weeks prior to a weight loss maintenance programme.17 Energy
intake is usually < 3350 kJ (800 kcal) per day.17
Food usually replaced with a nutritionally balanced product (e.g. shake, soup, bar) with high protein content to
minimise the loss of lean tissue, supplemented with vitamins, minerals, electrolytes and fatty acids.
Many people with type 2 diabetes who are overweight or obese can achieve remission if they lose > 15 kg of
body weight (see: “Weight loss for the prevention and treatment of diabetes”). May cause a reduction
Hard to sustain and often used for short periods. No guidance on food selection is provided therefore education
may be required to ensure healthy options are chosen during the weight maintenance phase. Not appropriate for many
people, e.g. children, pregnant women, people aged over 65 years, those with eGFR < 30 mL/min/1.73m2 or
recent acute coronary syndrome.7 The reduced energy intake may cause transient adverse effects including
alopecia, tiredness, dizziness and cold intolerance.
A pattern of eating that cycles between energy restriction and non-fasting. The most common is the 5+2 dietary
regimen where a normal calorie intake of healthy food is maintained for five days per week and substantially less eaten
on two days, e.g. 2100–2500 kJ (500-600 kcal) per day.
Time-restricted eating is another type of intermittent fasting that involves fasting for at least 12 hours every
24 hours, e.g. by abstaining from food from 7pm – 7am.18
Intermittent fasting is as effective as a continuous energy restricted dietary regimen in terms of weight loss.
However, some people may find intermittent fasting easier to adhere to rather than reducing the amount of food they
eat every day.
Little is known about the long-term risks and benefits. Fasting is associated with an increased risk of hypoglycaemia
in patients with type 2 diabetes who are taking sulfonylureas or insulin.19
Vegetarian or vegan
Vegetarian excludes meat as a source of food but includes egg and dairy. Vegan excludes all meat and animal-derived
Associated with a reduced risk of diabetes and lowered LDL-C.14
Requires calorie restriction to be effective for weight loss. May include high amounts of saturated fats, e.g.
coconut oil, and processed foods high in calories, sugar and sodium. Vegan regimens may be low in iron, vitamin B12,
calcium and iodine and supplementation may be beneficial.
Focuses on foods theoretically eaten during early human evolution, e.g. lean meat, fish, vegetables, eggs, nuts
and berries, and avoids grains, dairy, salt and refined fats and sugars.
Includes some patterns of behaviour known to be beneficial, e.g. drinking water, limiting refined sugar.
Only a few small studies of short duration have been conducted with mixed effects on weight, HbA1c and
lipids.14 Fibre and calcium intake may be insufficient. Foods marketed as “paleo” can be expensive.
* It is thought that these patterns of eating shift the body away from glucose as a source of energy and towards fatty
acids and fatty-acid derived ketones, at the same time fat storage is reduced.20
Exercise should be included in every weight loss programme
Exercise alone is less effective than a calorie-restricted diet for achieving weight loss.21 However, some
form of physical activity should be included in all weight loss interventions as it augments weight reduction and confers
additional benefits, e.g. improved cardiovascular and mental health. A synthesis of systematic reviews found that weight
loss interventions that included dietary advice, counselling and exercise were more effective than interventions including
dietary advice and counselling alone.22 Physical activity has also been shown to be beneficial in helping patients
maintain a reduced body weight once they have lost weight.23
Recommend that people start with exercise that they enjoy, are familiar with and is appropriate for their age and capabilities.
In general, weight bearing exercises are more effective at reducing BMI than non-weight bearing exercise. For example,
walking or jogging uses approximately 30% more energy over the same time period than swimming or cycling.24
The amount of exercise should be extended as fitness improves to increase the benefit, e.g. parking the car progressively
further away from the destination, getting off the bus several stops earlier, increasing the number of stairs that are
climbed or adding another type of activity.
Focus on cardiovascular as well as weight-based goals
Encourage people to focus on the range of benefits that exercise provides, rather than using body weight as the sole
measure of success. Focusing on weight alone may overlook other positive changes, e.g. increased muscle mass and fitness,
decreased central adiposity and better mental health.
How much physical activity is recommended?
Discussions with patients about physical activity can be guided by the following points:11
- Sit less and move more, e.g. after sitting for 30 minutes, get up from your seat and walk around
- Do at least 2.5 hours of moderate activity per week*, e.g. brisk walking, swimming, playing social games/sports, gardening, vacuuming, mowing the lawn.
This can be reduced by half if it is vigorous activity*, e.g. running, hill walking, fast cycling, aerobic dancing, competitive sports,
carrying heavy loads, shovelling/digging.
- For additional benefits increase the duration of moderate activity to five hours per week
- Perform muscle strengthening activities two days of each week
- Some level of physical activity is better than none
* Moderate activity noticeably accelerates heart rate; vigorous activity causes rapid breathing and a
substantial increase in heart rate. Exercise intensity is also dependent on fitness level.
Further information about different types of physical activities suitable for different age groups is available
Diabetes New Zealand provides exercise suggestions including activities appropriate for those with an injury
or disability, available from: www.diabetes.org.nz/type-2-diabetes-physical-activities
Maintaining positive change
Following a reduction in body weight, changes in appetite-regulating hormones make maintenance of weight loss difficult.
The hormone ghrelin that causes hunger may be increased for more than three years and leptin which decreases hunger is
suppressed.13 Furthermore, a person’s resting metabolic rate slows following weight loss which also makes weight
regain more likely.25
To counteract these physiological and metabolic changes people need long-term monitoring and support in primary care.
Other services and groups which can help include:
Group weight loss programmes are effective
Weight loss interventions may be delivered in groups, e.g. by a practice nurse, community organisations or by a commercial
provider. The advantage of this approach is that it provides a support network and allows people to share their experiences.
It is unclear what the most important factors influencing the success of group programmes are, however, those that provide
feedback, e.g. group weigh-ins, and dietary advice are more likely to be successful.26 There is evidence that
male-only group programmes are more effective than female-only programmes.26
There are many commercial weight loss programmes, however, relatively few have been studied in clinical trials. The
common feature of successful commercial programmes is a high level of engagement including, nutritional advice, physical
activity, self-monitoring, goal setting with individual or group sessions. The two most popular programmes that are supported
by evidence are Weight Watchers and Jenny Craig.27 A meta-analysis found that compared to people receiving
general education and counselling about weight loss, Jenny Craig was associated with 4.9% greater weight loss and Weight
Watchers was associated with 2.6% greater weight loss after 12 months (limited data are available beyond this point).27 The
Jenny Craig programme includes meals and therefore is more expensive than Weight Watchers.27
Little is known about the benefits of smart phone apps
Smart phone apps and activity tracking devices may be useful for some people to record (and potentially share) the duration
and intensity of exercise or monitor dietary intake. In general, mobile health technology is associated with positive
behaviour change, e.g. increased consumption of vegetables and fruits and more physical activity, however, little data
is available on long-term effectiveness.28
Dietary supplements: no evidence of effectiveness and may cause adverse effects
Advise people against using dietary supplements for weight loss as there is no evidence they are effective, they are
often expensive and therefore unaffordable for some people and can be associated with serious adverse effects.
Dietary supplements include unregulated synthetic and plant products. The safety and efficacy of these products has
usually not been established and there are concerns about interactions with medicines, direct toxicity and the presence
of undeclared prescription medicines.31, 32 The U.S. Food and Drug Administration has examined dietary supplements
and found hundreds that contain unsafe ingredients or compounds that have not been adequately studied, and undeclared
medicines, including diuretics, antidepressants and sibutramine which was removed from the market in 2010 due to its association
with cardiac dysfunction and stroke.33
Some dietary supplements contain caffeine or capsaicinoids that may increase energy expenditure by increasing metabolism,
but can also cause tachycardia, which can be particularly problematic for people with existing cardiac conditions.34,
35 Liver failure, colitis, rhabdomyolysis, anxiety and gastrointestinal irritation have also been reported following
the use of dietary supplements.34–36
The most common herbal preparations for weight loss usually contain Garcinia cambogia (malabar tamarind), Camellia
sinensis (green tea), Hoodia gordonii (cactus), Citrus aurantium (Bitter orange) or Coleus
forskohli (Indian coleus, similar to mint); none of which have clear evidence that they can cause long-term weight
loss in humans.37 A number of “slimming” teas contain senna, a naturally occurring stimulant laxative which
is also a prescription medicine; excessive use may cause nausea, vomiting and diarrhoea. High-fibre tablets are also
sometimes sold as appetite suppressants, although there is no evidence that these are effective for this purpose.
The bottom line is that there is no clear evidence that any alternative or complementary product can result in significant
weight loss, and patients should be informed of the limitations of using these products and warned about possible adverse
Further information on ingredients often found in dietary supplements is available from:
There are two medicines approved for weight loss in New Zealand, both unsubsidised: phentermine
and orlistat. These
medicines are associated with modest weight loss which needs to be balanced against the risk of adverse effects. Some
people may find the short-term use of weight-loss medicines helpful as an adjunct to lifestyle change. Current Ministry
of Health advice is that medicines for weight loss should only be considered if:3
- Lifestyle changes have failed to produce clinically significant benefits after six months
- The person has a BMI ≥ 30 kg/m2
Patients who are taking medicines for weight loss should be monitored monthly for the first three months.3 Treatment
beyond three months should not be considered unless the patient is tolerating the medicine, a clinically significant benefit
has occurred, e.g. ≥ 5% reduction in body weight, and there are no concerns about ongoing treatment.3
Phentermine has a limited role in the short-term treatment of obesity
Phentermine is a dopaminergic agonist that acts as an appetite suppressant. It is indicated as a short-term, i.e. 12
weeks or less, adjunctive treatment for weight loss in patients with a BMI greater 30 kg/m2.38 Phentermine
is contraindicated in a number of patients, especially those with cardiac abnormalities and hypertension.38 Phentermine,
like amphetamine, is a sympathomimetic drug and there are some concerns that it has addictive potential
(see the NZF for
dosing, adverse effects and interactions with other medicines). A four-week trial is recommended when initiating phentermine
and treatment beyond 12 weeks may be considered for patients who are continuing to lose weight,39 however,
prescribers should be alert to signs of dependence, e.g. requesting more than the maximum approved dose or lost prescriptions.
A small number of randomised controlled trials have reported a beneficial effect of phentermine on weight loss.40
For further information on the addictive potential of phentermine see:
“Is phentermine addictive?”
Orlistat reduces fat absorption and may cause gastrointestinal adverse effects
Orlistat is a selective inhibitor of pancreatic lipase that reduces the digestion and absorption of fat which is excreted
in the stool. To avoid an excessive amount of fatty or oily stools patients need to adhere to a low-fat diet. Orlistat
is contraindicated in patients with chronic malabsorption or cholestasis.38 Orlistat should be used with caution
in patients with chronic kidney disease or volume depletion.38
The adverse effects of orlistat can be significant and include faecal urgency, flatulence, cramps, bloating and impaired
absorption of fat-soluble vitamins, e.g. A,D,E and K.38 The presence of symptoms may indicate that the patient
is eating too much fat, which may motivate them to reduce their intake.38 Fewer than 10% of patients who begin
treatment with orlistat continue treatment beyond one year.3 Slowly titrating the dose of orlistat or adding
psyllium fibre to the diet may reduce gastrointestinal adverse effects (see the NZF for
dosing, adverse effects and interactions with other medicines).25
The percentage of patients taking orlistat who are able to achieve a 5% reduction in body weight after 12 months ranges
from 35 – 73%.41
Metformin may be considered for people at high risk of type 2 diabetes
Metformin is the first-line medicine for most patients with type 2 diabetes who are obese. The main actions of metformin
are to decrease gluconeogenesis and increase peripheral utilisation of glucose (see the NZF for
dosing, adverse effects and interactions with other medicines).38
The use of metformin may contribute to weight loss and the prevention of diabetes (unapproved indication) in people
who are at high risk of type 2 diabetes, i.e. HbA1c 41–49 mmol/mol. It is also sometimes used as a weight loss
medicine in people with a HbA1c ≤ 40 mmol/mol (unapproved indication). A meta-analysis of three studies found
that in people without diabetes who were overweight or obese (HbA1c not reported), treatment with metformin
for three to four months resulted in a 2.3 kg reduction in weight, compared to people treated with a placebo.42
Bariatric surgery is a major and generally irreversible weight loss procedure. It is effective for motivated patients
who are able to maintain lifelong altered eating habits and lifestyle change.3 One year after bariatric surgery
weight loss can be 40–50 kg with significant improvements in blood pressure, lipid levels and HbA1c (including
remission of diabetes), obstructive sleep apnoea, gastro-oesophageal reflux and venous circulation expected.3 The
Swedish Obese Subjects study found a mean reduction in body weight of 18% twenty years after bariatric surgery in a large
group of patients.43
Referral for bariatric surgery
The Ministry of Health’s criteria for consideration of publicly funded bariatric surgery are:3, 44
- A BMI 35–55 kg/m2, but body weight less than 160 kg, and co-morbidities, e.g. diabetes, sleep apnoea, hypertension,
hypercholesterolaemia, infertility or arthritis
- Stable living arrangements and strong social supports
- No substance addiction, including nicotine; smoking cessation is required at least six weeks prior to surgery
- A willingness to accept life-long monitoring
Referrals for surgery are reviewed within each DHB by a team who apply a national scoring system to determine who will
receive the greatest benefit.3 Bariatric surgery can also be accessed privately; acceptance criteria is likely
to vary between clinics. A multidisciplinary team including a dietitian and a psychologist work with the primary care
team to evaluate and monitor the patient before and after surgery.3 Bariatric surgeries are performed laparoscopically
and the risk of complications depends on the type of surgery.
Supporting patients who have undergone bariatric surgery
The goal during the first one to eight weeks following bariatric surgery is to maintain hydration and to ensure protein
and nutrient intake is sufficient to allow healing and prevent muscle loss while the patient returns to solid food.45
The long-term use of a complete mineral and multivitamin supplement is recommended containing iron, folic acid, thiamine
and vitamin B12.44 Request a full blood count and analysis of iron, vitamin B12, serum calcium, magnesium,
phosphate and albumin every six months for the first two years and then annually.45
Alcohol should be avoided or drunk in moderation as its metabolism may be impaired following bariatric surgery.44 Pregnancy
is not recommended for at least two years following bariatric surgery.3
Weight loss is a journey rather than a destination, both for patients and the health professionals assisting them. The
long-term lifestyle changes needed to achieve sustainable weight loss require ongoing support from family, friends and
health professionals. This support is particularly important when people stumble, as they inevitably will; resilience
and determination are required. The continuing role of the primary care team is to encourage people to maintain positive
change and to offer additional advice as people age and their health or circumstances change.