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Case 1: A 15 year old female wants treatment for her acne. She has multiple open and closed comedones and a few inflammatory lesions.
Case 2: A 16 year old male presents requesting treatment for his acne. He informs you that he has had acne for a year and has tried benzoyl peroxide and topical tretinoin. He has moderately severe facial acne with multiple papules, pustules and comedones, and scattered inflammatory lesions on his shoulders.
You ask him to continue a topical retinoid or benzoyl peroxide.
The acne in the previous case did not significantly improve after a 6 month course of appropriate therapy. After discussion with the patient you have decided to try isotretinoin