Adverse drug reactions and interactions

Proton pump inhibitors and the risk of acute kidney injury

Proton pump inhibitors (PPIs) are among the most prescribed...

August 2016

Alcohol misuse: how to help patients in primary care

Approximately one in five New Zealanders over the age of 15...

May 2016

Using the NZF Interactions Checker

The New Zealand Formulary (NZF) contains a function that identifies...

December 2015

Upfront: An avoidable death: the importance of communication in clinical care

The following treatment injury case study was prepared by the...

August 2015

Do probiotics provide effective and safe protection against antibiotic-associated adverse effects?

Sales of probiotic products in the community generate billions...

June 2015

Safer prescribing of high-risk medicines - Methotrexate: potentially fatal in overdose

Low-dose methotrexate is commonly used in the treatment of patients...

October 2014

Safer prescribing of high-risk medicines: Colchicine – extremely toxic in overdose

Colchicine is a plant-based alkaloid, extracted from Colchicum...

September 2014

Safer prescribing of high-risk medicines: Clozapine

Pharmacological treatment is an integral part of the practice...

July 2014

Hazardous substances series: Pyrethroid toxicity and its management

Contributed by Dr Michael Beasley and Dr Wayne Temple, National...

December 2013

Long-term Use of Corticosteroids: Think about Bone Health

Bone density loss leading to osteoporosis is a risk for patients...

November 2013

Non-steroidal anti-inflammatory drugs (NSAIDs): Making safer treatment choices

Non-steroidal anti-inflammatory drugs (NSAIDs) are successfully...

October 2013

Ticagrelor – out with the old, in with the new?

Ticagrelor (Brilinta) is a new oral antiplatelet medicine, which...

August 2013

Statins and the risk of acute kidney injury

THERE HAVE BEEN RECENT REPORTS in the literature associating...

April 2013

Hypomagnesaemia with proton pump inhibitors

IN DECEMBER, 2012 MEDSAFE published a warning on the risk of...

April 2013

H1N1 influenza vaccination and the risk of childhood narcolepsy

IN MARCH, 2012 A SIGNIFICANT INCREASE in the rate of childhood...

April 2013

Dabigatran revisited

Dabigatran has been available for general practitioners to prescribe...

February 2013

Appropriate use of sulfonamides

What are sulfonamides and how do they work? | Prescribing co-trimoxazole...

December 2012

Appropriate use of tetracyclines

What are tetracyclines and how do they work? | Which infections...

October 2012

Medicines interactions: using the New Zealand Formulary

How to interpret Stockley's Interaction Alerts How to use the...

September 2012

The appropriate use of macrolides

Macrolides are a class of antibiotic that includes erythromycin,...

May 2012

Prescribing citalopram safely: an update

Evidence of adverse cardiac effects associated with citalopram...

February 2012

News in brief: Maternity referral guidelines & Simvastatin


• New maternity referral guidelines released
• Simvastatin:...

September 2011

News in brief: Dabigatran; Antibiotics and COC; Prescription kitchen

Dabigatran to be listed | Most broad spectrum antibiotics do...

June 2011

Quinolone antibiotics - limit use

Quinolones are associated with increasing antimicrobial resistance....

April 2011

Methotrexate prescribing errors can be fatal

When used and monitored correctly methotrexate can be an effective...

February 2011

Snippets: Jadelle & Sibutramine

Jadelle – A newly funded long-acting contraceptive implant |...

November 2010

The warfarin dilemma

Evidence suggests that warfarin is under utilised in older people....

October 2010

Snippets: Iodine supplements Zoledronic acid & Atorvastatin


• Iodine supplements now funded
• Zoledronic acid now funded
• Atorvastatin...

August 2010

TNF inhibitors - an update

Tumour necrosis factor (TNF) inhibitors are used in the treatment...

November 2009

Prescribing issues associated with anticonvulsant medications for epilepsy

The goal of successful pharmacological treatment in epilepsy...

November 2009

Oxycodone: place in therapy

Oxycodone is a strong opiod and is a second line option (after...

November 2009

Low molecular weight heparin use in primary care

Enoxaparin (Clexane) is a low molecular weight heparin used...

November 2009

Practice tips: PPIs and Paraffin

All about PPIs, Fire hazard with paraffin

September 2009

Pharmacological Management of Depression in Adults

All antidepressant drugs are approximately equal in effectiveness,...

July 2009

Monitoring of generic medicines and brand changes

Dr Michael Tatley of CARM advises on how brand changes are...

July 2009

Fluoroquinolone-associated tendon disorders

The use of oral fluoroquinolones is associated with increased...

June 2009

Adverse reaction reporting tool

On April 1 2009, the Minister of Health launched a new electronic...

June 2009

Upfront: The isotretinoin debate

There are two major safety concerns with isotretinoin :
• It...

April 2009

The role of antiplatelet agents

Antiplatelet drugs including aspirin, clopidogrel and dipyrimadole,...

February 2009

WHO Analgesic Ladder: Methadone - safe and effective use for chronic pain

Methadone is a strong opioid that may be suitable for people...

December 2008

Anticholinergics for COPD

Two recent studies have raised concern that the use of ipratropium...

December 2008

Rheumatoid arthritis - monitoring of DMARDs

Most people with rheumatoid arthritis require early treatment...

October 2008

Medication-overuse headache: when the cure becomes the cause

Medication-overuse headache is a complex disorder best described...

September 2008

Clozapine: A reminder about safe and effective use

Although clozapine is a specialist prescribed drug, GPs still...

June 2008

Snippets: Anticonvulsants & Salbutamol

Anticonvulsants and suicide, subsidy changes for salbutamol,...

June 2008

Snippets: Varenicline & Smoking

Varenicline and suicidal behaviour. Wider access to quit cards.The...

May 2008

Combined oral contraceptives: Issues for current users

Oral contraceptives are used by 147,000 New Zealand women. This...

April 2008

Snippets: NSAIDs dextropropoxyphene and antibiotic resistance

Drug information of topical interest

February 2008

Snippets: Drug information of topical interest


• Calcium Supplementation and the risk of myocardial infarction
• Use...

December 2007

Dear Dave


• Breakthrough Bleeding
• Camphor in Pregnancy

December 2007

Dear Dave

Does the "seven day rule" still apply with the concomitant...

September 2007

Lumiracoxib linked to deaths in Australia

Medsafe have just announced that approval for lumiracoxib (Prexige)...

September 2007

Dear Dave

Can Sumatriptan be used safely with SSRIs? Can you ever use...

August 2007

Dear Dave

What is the significance of the warning between ACE inhibitors...

June 2007

CARM reports: Acute Renal Failure

In the five years from 2002 to 2006 CARM (Centre for Adverse...

June 2007

Clozapine - Safe and Effective Use

Clozapine is the gold-standard treatment for people with schizophrenia...

April 2007

Dear Dave

Is there an association between the use of the combined oral...

April 2007

Interactions with Warfarin

Warfarin has the potential to interact with numerous drugs resulting...

April 2007

Drug Interactions with Antidepressants

Table of important drug interactions with antidepressant ...

March 2007

The CYP450 System

An overview of the CYP450 system with particular reference to...

March 2007

CARM Reports; Serotonin Syndrome and Neuroleptic Malignant Syndrome

Covers the symptoms and causes of Serotonin Syndrome and Neuroleptic...

February 2007

Dear Dave

Can smoking cessation affect the dose of antipsychotics?Do statins...

February 2007

Lithium in General Practice

In this article we provide an overview and guidance on the management...

February 2007

Amiodarone:- safety issues

Reducing adverse events in patients taking amiodarone.

December 2006

Dear Dave

SSRIs can increase the risk of bleeding disorders, especially...

December 2006

TCAs are useful for depression and neuropathic pain

Tricyclic antidepressants (TCAs) are an effective alternative...

December 2006

Ten minute audit

Identifies people under the age of 18 years on paroxetine to...

October 2006

NSAIDs and coxibs

Cardiovascular risk associated with NSAIDs and coxibsNSAIDs...

October 2006

Polypharmacy at the Primary-Secondary interface

Polypharmacy due to multiple physician involvement in patient...

October 2006

Polypharmacy

We have defined polypharmacy as the addition of one or more...

May 2006

Appropriate use of cephalosporins

There are very few indications for the use of cephalosporins...

December 2011

Made with by the bpacnz team